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There were similar rates of mild adverse events (e.g., nausea, restlessness, insomnia, irritability) across groups in trials of cytisine based on our initial overview.22 However, an updated Cochrane review on cytisine42 suggested there may be a small increase in adverse events, which could constitute a small harm (4 RCTs, n = 4052
CAT is a validated health status questionnaire for use in COPD patients with a 2 unit change considered to be of minimal clinical important difference
As these companies continue to innovate and adapt to shifting consumer demands and a complex regulatory environment, their actions will undoubtedly define the future of tobacco and nicotine consumption in the United States for years to come